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Off-Center Fold
March 1998

Fever and Rash Complicating a Leg Ulcer

Author Affiliations


Arch Dermatol. 1998;134(3):365-370. doi:

The biopsy specimen showed vacuolar alteration of the basal layer, papillary edema, and a superficial and middermal perivascular, periadnexal, and interstitial lymphohistiocytic infiltrate with occasional neutrophils (Figure 3). In some areas, extensive lymphocytic infiltrate was seen blurring the outlines of vessels (Figure 4). No features of vasculitis were seen.