Gnathostomiasis is primarily a disease of the skin characterized as a creeping eruption or mobile erythema.1 Infection in humans usually occurs by ingesting the raw or undercooked flesh of freshwater fish.1 In addition to fish, an array of animals, such as amphibians, reptiles, and birds, can serve as the paratenic host for Gnathostoma species, so that infection in humans could also occur if these animal meats were ingested raw.1 We describe 6 patients with gnathostomiasis who were infected by eating the flesh of a poisonous snake, Agkistrodon halys (common name, Mamashi), in Japan.