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June 1998

Human Herpesvirus 8 as the Infectious Cause of Kaposi Sarcoma: Evidence and Involvement of Cofactors

Arch Dermatol. 1998;134(6):736-738. doi:10.1001/archderm.134.6.736

KAPOSI SARCOMA–ASSOCIATED human herpesvirus, or human herpesvirus 8 (HHV-8), DNA sequences were first identified in 1994 using representational difference analysis on Kaposi sarcoma (KS) and healthy tissue from a patient seropositive for the human immunodeficiency virus (HIV).1 Until now, HHV-8 has been definitively associated with 3 human diseases: KS, primary effusion lymphoma (PEL) (also called body cavity–based lymphoma),2 and multicentric Castleman disease.3

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