A 65-year-old black woman presented for evaluation of diffuse hypopigmentation of her extremities. The hypopigmentation had been present for approximately 1 year and was asymptomatic. The patient's medical history was significant for sarcoidosis. Physical examination revealed numerous guttate hypopigmented macules of the extremities (Figure 1 and Figure 2). The histopathologic features of a biopsy specimen from a hypopigmented macule are shown in Figure 3 and Figure 4.
Mashek H, Kalb R. Hypopigmentation of the Extremities. Arch Dermatol. 1998;134(6):743–748. doi:
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.