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July 1998

DIDMOHS: A Proposed Consensus Nomenclature for the Drug-Induced Delayed Multiorgan Hypersensitivity Syndrome—Reply

Arch Dermatol. 1998;134(7):876. doi:

In reply

Drug-induced hypersensitivity syndromes are associated with a variety of different drugs and have been recognized for many years. In previous studies and case reports, we usually defined the syndrome as a triad of fever, skin rash, and single or multiple internal organ involvement that starts within 8 weeks after initiation of therapy.1-4 However, the variable presentation with a wide variety of abnormal clinical and laboratory manifestations and the multitude of different synonyms used to describe this entity can make diagnosis or a literature search difficult and may contribute to the general unfamiliarity that physicians seem to have with this syndrome.