Isotretinoin was shown to be effective in patients with treatment-resistant rosacea by Nikolowski and Plewig1 in 1980 for the first time. Since then, many other studies2-4 confirmed its efficacy in a daily dose of 0.5 to 1.0 mg/kg. However, it has also been noted that adverse effects of the drug may limit its use. In this study, we aimed to determine if low doses of isotretinoin were effective in patients with treatment-resistant rosacea.
Erdogan FG, Yurtsever P, Aksoy D, Eskioglu F. Efficacy of Low-Dose Isotretinoin in Patients With Treatment-Resistant Rosacea. Arch Dermatol. 1998;134(7):884–885. doi:
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