In response to the letter of Cathomas et al, there are several possible explanations why they were unable to detect HHV-8 DNA or anti–HHV-8 antibodies in their patients. The most obvious possibility is the absence of HHV-8, which should not be surprising considering that the medical literature reflects differing prevalences of the virus in different populations.1
Tyring SK. No Evidence of HHV-8 Infection in Patients With Pemphigus Vulgaris/Foliaceus—Reply. Arch Dermatol. 1998;134(9):1162. doi:
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