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October 1998

Porphyria Cutanea Tarda Induced by the Use of Pravastatin

Arch Dermatol. 1998;134(10):1305-1306. doi:

Porphyria cutanea tarda (PCT) is a photodermatosis with an onset usually occurring in patients in their third decade. Although most cases are sporadic, autosomal dominant inheritance of the disorder has been reported. In most patients, a deficiency of the uroporphyrinogen III decarboxylase is noted. Skin symptoms include vesicular, bullous, and ulcerative lesions primarily on light-exposed sites due to increased skin fragility, milia on hands, hypertrichosis, and periorbital suffusion. In about 25% of the patients diabetes is found and about one third of patients show elevated plasma iron levels. Patients with PCT excrete elevated amounts of porphyrins in the urine with a characteristic pattern (increased excretion of uroporphyrins I and III and isocoproporphyrins).1