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October 2014

The Clinical Presentation of the High-Mitotic-Rate Melanoma

Author Affiliations
  • 1David Geffen School of Medicine at University of California, Los Angeles
  • 2Division of Dermatopathology, Department of Pathology and Laboratory Medicine, University of California, Los Angeles Medical Center, Los Angeles
JAMA Dermatol. 2014;150(10):1047. doi:10.1001/jamadermatol.2014.924

Reason dictates that rapidly growing melanomas carry a worse prognosis than those that are quiescent. Indeed, much focus has been given to calculating the growth index of melanomas as defined by their mitotic rate1,2—a process that requires counting the number of mitoses in several high-power fields. As expected, mitotic rate has been found to correlate with and predict morbidity and mortality for melanoma2 and therefore has become a routine part of the histologic examination of these tumors.3

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