ASPERGILLOSIS CAN present as either an invasive or cutaneous infection. In the first instance, 1 or multiple organs are invaded, and hemorrhagic infarcts are very likely to develop. This occurs particularly when the patient is profoundly neutropenic due to underlying disease or therapy. In the latter instance, aspergillosis is apparent in the skin and can present (1) as primary cutaneous aspergillosis (PCA) derived from direct external inoculation through contact with objects such as armboards, external catheter sites, or surgical or other traumas; or (2) as secondary cutaneous aspergillosis caused by dissemination of the invasive disease to the skin.
Emmanuel Roilides, Evangelia Farmaki. Human Immunodeficiency Virus Infection and Cutaneous Aspergillosis. Arch Dermatol. 2000;136(3):412–414. doi:10.1001/archderm.136.3.412