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Evidence-Based Dermatology: Research Commentary
June 2000

Advantage of Smaller Trials for the Widespread Use of Sedative Drugs

Arch Dermatol. 2000;136(6):772-773. doi:10.1001/archderm.136.6.772

The Effect of Nitrazepam on Nocturnal Scratching in Adults With Atopic Dermatitis: A Double-Blind Placebo-Controlled Crossover StudyEbata T, Izumi H, Aizawa H, Kamide R, Niimura MBr J Dermatol. 1998;138:631-634

Sedative antihistamines and benzodiazepines are often prescribed to patients with atopic dermatitis (AD) to reduce nocturnal itching and scratching, but their effects have been poorly studied. The objective of this double-blind, placebo-controlled, crossover trial was to assess the effect of nitrazepam on nocturnal scratching of 10 adult patients with AD by means of both objective and subjective outcome measures.