RECENTLY, IN the climate of a growing interest in alternative medicine, the use of botanicals in skin care products has received considerable attention by researchers, industry, consumers, and the news media—particularly for the protection of human skin from the damaging effects of external environmental stimuli, such as solar UV radiation. In this regard, the botanicals possessing antioxidant properties are the most studied group of agents. There are extensive preclinical efficacy data in mouse models concerning protection against UV radiation–induced immunosuppression, inflammation, and/or cancer by antioxidants, such as vitamin E,1 green tea polyphenols,2 garlic,3 ginger,4 carnosine,5 and vitamin C.6 Subsequently, clinical efficacy data in human subjects have been produced regarding green tea polyphenols7,8 and all-trans retinoic acid.9
Wood GS. Green Tea: What's Brewing? Arch Dermatol. 2000;136(8):1051. doi:10.1001/archderm.136.8.1051
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