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October 2000

Generalization of Cicatricial Pemphigoid During Azathioprine Therapy

Arch Dermatol. 2000;136(10):1274. doi:

Cicatricial pemphigoid (CP) is a variant of pemphigoid and is described as a chronic autoimmune bullous disease characterized by subepithelial blistering of mucous membranes with or without skin involvement. Clinical manifestations include characteristic scarring; oral, nasal, and vaginal mucous membrane lesions; erosive stomatitis; gingivitis; and ocular scarring. The usual presentation occurs in the fifth or sixth decade of life. Treatment regimens include systemic corticosteroids and immunosuppressive agents, including azathioprine and cyclophosphamide used in rapidly advancing disease states.1