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February 2010

Monoclonal Gammopathy of Undetermined Significance and Incidentally Identified Cutaneous Monotypic Plasma Cell Infiltrates in the Absence of Specific Skin Lesions

Author Affiliations

Author Affiliations: Department of Dermatology, University of Connecticut Health Center, Farmington.

Arch Dermatol. 2010;146(2):204-206. doi:10.1001/archdermatol.2009.387

The present case highlights the nosologic complexity of monoclonal gammopathy (MG) associated with monotypic plasma cellular infiltrates in the absence of specific clinical skin lesions or systemic involvement.

An 85-year-old woman presented for basal cell carcinoma (BCC) reexcision from her right leg. She had a history of MG since 1996, with 6% plasma cells in her bone marrow at that time. No skin lesions clinically suggestive of plasmacytoma or cutaneous involvement by multiple myeloma (MM) or evidence of end-organ failure (ie, anemia, hypercalcemia, or renal insufficiency) were seen at any time.

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