The incidence of invasive melanoma in the United States continues to rise 4% to 6% annually despite all of our efforts to improve primary prevention. Similar increases are being noted worldwide. It was estimated that 68 720 Americans will have been diagnosed as having melanoma in 2009, and the current lifetime risk for developing invasive melanoma is 1 in 58.1 When the estimated 53 120 cases of in situ melanoma are added, the lifetime risk for being diagnosed as having melanoma is now 1 in 30. Also, it was estimated that 8650 Americans died of melanoma in 2009.