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A 29-year-old man with chronic lymphedema in the left lower extremity for 8 years presented with an enlarging and ulcerated nodular plaque on his left leg. The lesion had started out as a bruise, then progressively enlarged and ulcerated over 4 months. He went to many physicians during this time and was tested and/or treated for possible infection, deep vein thrombosis, vasculitis, anda torn muscle. The patient's family history was remarkable in that his mother and sister both have chronic bilateral lymphedema.
Cronin H, Mowad C, Ferringer T. Large Nodular Plaque on Leg in the Setting of Chronic Lymphedema—Quiz Case. Arch Dermatol. 2010;146(3):337–342. doi:10.1001/archdermatol.2010.6-a