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JAMA Dermatology Clinicopathological Challenge
June 2015

Spontaneous Regression of an Infantile Scalp Tumor

Author Affiliations
  • 1Dermatology resident, Hospital Arnau de Vilanova, Valencia, Spain
  • 2Department of Dermatology, Hospital Universitario del Niño Jesús, Madrid, Spain
JAMA Dermatol. 2015;151(6):663-664. doi:10.1001/jamadermatol.2014.4985

A newborn girl with a nodular lesion on the scalp present since birth was seen at the dermatology clinic. The parents reported occasional erosions and crusting that resolved with topical mupirocin, 2%, cream, but with no continued growth. The mother had had a normal pregnancy. Physical examination revealed a firm, exophytic, and flat-topped nodule, with superficial erosion and crust on the right parietal side of the scalp measuring 3 cm in diameter and 1 cm thick (Figure, A). No other skin lesions were found. A 4-mm punch skin biopsy was performed, and tissue was sent for pathologic analysis (Figure, B and C). Cerebral and abdominal ultrasonography revealed no evidence of visceral involvement. The lesion regressed without treatment over a period of 8 months. Close follow-up every 3 months was scheduled, and complete involution of the tumor was noted at 10 months of age (Figure, D).

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