Wouldn’t it be great to have a device in your examination room to perform an “optical biopsy”? The human eye alone can get you just so far in dermatology. Even the finest morphologist often requires an invasive biopsy and histopathologic evaluation to arrive at a conclusive diagnosis. Apart from simple dermoscopy, optical interrogation of the skin is not routinely used in our field and has largely been confined to the experimental laboratory, but recent developments may stimulate interest in bringing diagnostic optical technologies into the clinic.