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December 2015

Partial Histological Tumor Regression in Primary Melanoma as Protective Factor for Lymph Node Micrometastasis

Author Affiliations
  • 1Center for Dermato-oncology, Department of Dermatology, University Hospital Tübingen, Tübingen, Germany
JAMA Dermatol. 2015;151(12):1291-1292. doi:10.1001/jamadermatol.2015.2236

Partial histological tumor regression in primary melanoma is a rather frequent event and has been reported in 10% to 35% of primary melanomas. Partial histological tumor regression is defined as an area within the tumor where melanoma cells have disappeared and are substituted by scarring and melanophages.1 Clinically, a skin-colored or depigmented area develops within the tumor. Regression is a clinical and dermoscopic criterion for the melanoma diagnosis. Partial tumor regression with scarring does not occur in benign melanocytic nevi.

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