Potrony et al1 studied a new category of cancer susceptibility genes conferring a moderately increased risk of developing cancer: a mutational hotspot in the microphthalmia transcription factor (MITF) gene, p.E318K.2,3 The main melanoma risk factors are UV light exposure and genetically determined host factors, such as nevus phenotype (atypical and multiple), fair skin, and familial or personal history of melanoma.
Bressac-de Paillerets B, Vabres P, Thomas L. Genetic Testing for Melanoma—Where Are We With Moderate-Penetrance Genes?. JAMA Dermatol. 2016;152(4):375–376. doi:10.1001/jamadermatol.2015.4359