A woman in her 20s presented to our department for treatment of multiple facial papules. The lesions were present since childhood, progressively increasing in number. They involved primarily her face, and, less so, her extremities and trunk. There was no medical history of spontaneous regression. She had a young brother, who had the same papular lesions that had followed the same natural history, displaying a similar bodily distribution although fewer in number. Previous studies and imaging of the 2 siblings had failed to reveal any systemic findings.