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January 2017

Immunoglobulin E Autoantibodies in Bullous Pemphigoid Detected by Immunoglobulin E Enzyme-Linked Immunosorbent Assays

Author Affiliations
  • 1Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, Japan
  • 2Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan
  • 3Department of Dermatology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
JAMA Dermatol. 2017;153(1):15-17. doi:10.1001/jamadermatol.2016.4593

Autoimmune bullous diseases (AIBDs) exhibit an immunoglobulin (Ig) G and/or IgA antibody response to various cutaneous autoantigens.1 Immunoglobulin G antibasement membrane zone autoantibodies in bullous pemphigoid (BP) sera react with BP180 and BP230.1-4 While the pathogenic role of BP180 was confirmed by various disease models,5,6 production of autoantibodies to BP230 was considered an epiphenomenon. The commercial availability of IgG enzyme-linked immunosorbent assays (ELISAs) for both BP180 and BP230 makes it possible to more closely examine this premise.3,4

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