Papulovesicular Eruption in a Pregnant Woman With Darier Disease

A primigravida woman in her 30s at 35 weeks’ gestation and with a history of Darier disease was admitted with an acute, painful eruption on her face and neck. She reported no history of pregnancy-related complications. Physical examination revealed confluent erythema with keratotic papulovesicles distributed on the face and neck (Figure, A). Honey-colored crusts were present on the left ear and preauricular area. The chest and inframammary area displayed occasional red, crusted papules. Laboratory tests revealed an elevated white blood cell count of 17.18 × 10³/μL (reference range, 4.50-11.00 × 10³/μL). A shave biopsy specimen and tissue culture were obtained from the center of an umbilicated papule on the neck (Figure, B and C).