Aloe vera, or Aloe barbadensis, is perhaps the most ubiquitous plant in skin care products across the world and was used even in ancient Greece, Rome, Babylonia, and China. Historical evidence suggests that both the leaf and pulp of this plant have been used extensively to treat dermatological ailments and were believed to prevent skin senescence, acne, psoriasis, relieve pruritus, prevent premature graying of the hair, improve alopecia, and promote wound healing.1 This Notable Note addresses the myriad of conditions aloe alleviates and provides a brief historical perspective of this “plant of immortality.”