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February 2017

Unusual Presentation of Poppers Dermatitis

Author Affiliations
  • 1Dermatologic Infectious Diseases Unit, San Gallicano Dermatological Institute, Rome, Italy
  • 2Dermathopathology Unit, San Gallicano Dermatological Institute, Rome, Italy
  • 3Viral Immunodeficiency Unit, National Institute for Infectious Diseases “Lazzaro Spallanzani,” Rome, Italy
JAMA Dermatol. 2017;153(2):233-234. doi:10.1001/jamadermatol.2016.4262

Cutaneous adverse effects of alkyl nitrites (“poppers”) are underestimated because the drug is generally used as an inhalant. Poppers can cause irritant or allergic contact dermatitis, especially on the face, with exceptional cases in other areas of the body.1-3 We report a unique case of an ulcer of the penis secondary to poppers toxic effects in a homosexual man, highlighting the importance of including exogenous chemical agents in the differential diagnosis of genital ulcers in men who have sex with men (MSM).