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JAMA Dermatology Clinicopathological Challenge
August 2017

Reticulate Hyperpigmentation in a Man With Hypohidrosis and Sinopulmonary Infections

Author Affiliations
  • 1Department of Dermatology, University of Florida College of Medicine, Gainesville
  • 2Utah Pathology Services, Inc, Salt Lake City
  • 3Department of Pathology, University of Utah School of Medicine, Salt Lake City
JAMA Dermatol. 2017;153(8):817-818. doi:10.1001/jamadermatol.2017.0046

A man in his 30s presented with reticulate hyperpigmentation, progressive since early childhood, overlying the trunk and extremities (Figure, A and B). Physical examination revealed normal fingernails and toenails, dermatoglyphics, and dentition. Additionally, there was no evidence of alopecia or keratoderma. Review of systems was remarkable for hypohidrosis, photophobia, and a history of recurrent sinopulmonary infections, including pneumonia, requiring hospitalization. Family history was notable for similarly affected men on the patient’s mother’s side. A punch biopsy specimen was obtained (Figure, C and D).

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