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Comment & Response
June 2017

Detection of Occult Invasion in Melanoma In Situ

Author Affiliations
  • 1Department of Pathology, Yale School of Medicine, New Haven, Connecticut
  • 2Department of Dermatology, Yale School of Medicine, New Haven, Connecticut
JAMA Dermatol. 2017;153(6):611. doi:10.1001/jamadermatol.2017.0196

To the Editor Bax et al1 recently identified individual cells and aggregates in the papillary dermis of recut sections in 12 of 34 melanomas in situ. In 6 of those 12 cases, the cells of interest resembled intraepithelial melanoma cells cytologically, while in the remaining cases, the cells of interest lacked typical cytopathologic features of melanoma but were confirmed by staining with both melan-A and SOX10 biomarkers.

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