Immune reactions in benign melanocytic nevi (BMN) without halo phenomenon are extremely rare, although humoral and cellular immune responses are involved in their development. Herein, we report a rare case of a patient with metastatic melanomas who showed a remarkable clinical response to nivolumab with a simultaneous prominent immune reaction in multiple BMN without halo phenomenon.
An adult woman with melanoma underwent a wide local excision and sentinel node biopsy. A left ilioinguinal lymphadenectomy was added because of a sentinel node micrometastasis. She also had dome-shaped, brown, soft nodules (≤8 mm; unchanged since puberty) on her face, shoulder, and neck, clinically diagnosed as typical BMN on initial examination.
Nakamura Y, Fujino T, Kagamu H, et al. Induction of Immune Reaction in Benign Melanocytic Nevi Without Halo During Nivolumab Therapy in a Patient With Melanoma. JAMA Dermatol. 2017;153(8):832–834. doi:10.1001/jamadermatol.2017.0615
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: