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Observation
August 2017

Induction of Immune Reaction in Benign Melanocytic Nevi Without Halo During Nivolumab Therapy in a Patient With Melanoma

Author Affiliations
  • 1Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center, Saitama, Japan
  • 2Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan
  • 3Department of Respiratory Medicine, Saitama Medical University International Medical Center, Saitama, Japan
JAMA Dermatol. 2017;153(8):832-834. doi:10.1001/jamadermatol.2017.0615

Immune reactions in benign melanocytic nevi (BMN) without halo phenomenon are extremely rare, although humoral and cellular immune responses are involved in their development. Herein, we report a rare case of a patient with metastatic melanomas who showed a remarkable clinical response to nivolumab with a simultaneous prominent immune reaction in multiple BMN without halo phenomenon.

An adult woman with melanoma underwent a wide local excision and sentinel node biopsy. A left ilioinguinal lymphadenectomy was added because of a sentinel node micrometastasis. She also had dome-shaped, brown, soft nodules (≤8 mm; unchanged since puberty) on her face, shoulder, and neck, clinically diagnosed as typical BMN on initial examination.

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