In Reply We appreciate the interest of Vignon-Pennamen et al in our study1 on histiocytoid Sweet syndrome (HSS). Like us, they consider the cells of the infiltrate as immature myeloid cells rather than M2 macrophages, and for them, too, this histopathologic variant of Sweet syndrome should not be considered a form of leukemia cutis; these were the 2 main goals of our study.