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JAMA Dermatology Clinical Evidence Synopsis
August 2017

Antibiotic Resistance in Acne Treatment

Author Affiliations
  • 1Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles
  • 2Drexel University College of Medicine, Philadelphia, Pennsylvania
JAMA Dermatol. 2017;153(8):810-811. doi:10.1001/jamadermatol.2017.1297

Clinical Question  What is the evidence for antibiotic resistance in acne, and how does resistance affect treatment?

Bottom Line  Use of topical and systemic antibiotics for acne is associated with formation of resistance in Propionibacterium acnes and other bacteria, with clinical consequences. Guidelines recommend resistance reduction strategies including avoidance of antibiotic monotherapy, combination treatment with topical modalities, and limiting the duration of oral antibiotic use.