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Brief Report
November 2017

Prevalence and Characteristics of Nonblanching, Palpable Skin Lesions With a Linear Pattern in Children With Henoch-Schönlein Syndrome

Author Affiliations
  • 1Pediatric Unit, Fondazione Ca’ Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy
  • 2Department of Pediatrics, University Children’s Hospital of Bern, Inselspital, Bern, Switzerland
  • 3Pediatric Department of Southern Switzerland, Bellinzona, Switzerland
  • 4Università della Svizzera Italiana, Lugano, Switzerland
JAMA Dermatol. 2017;153(11):1170-1173. doi:10.1001/jamadermatol.2017.2105
Key Points

Question  Do linear nonblanching skin lesions occur in children with Henoch-Schönlein syndrome?

Findings  In this case series of 31 children with Henoch-Schönlein syndrome, 8 children had linear nonblanching skin lesions on the legs, groin, waistline, wrists, or forearms.

Meaning  Physicians should evaluate children with Henoch-Schönlein syndrome for the presence of linear nonblanching skin lesions.

Abstract

Importance  Linear nonblanching skin lesions are thought to occur very rarely in patients with Henoch-Schönlein syndrome.

Objective  To examine the prevalence and characteristics of linear nonblanching skin lesions in children with Henoch-Schönlein syndrome.

Design, Setting, and Participants  A prospective case series was conducted at the ambulatory practice of a hospitalist between January 1, 2010, and December 31, 2015, among 31 consecutive children with Henoch-Schönlein syndrome.

Participants  Thirty-one consecutive children affected with Henoch-Schönlein syndrome who were from 3.0 to 12.0 years of age (median age, 6.2 years).

Main Outcome and Measures  Children with Henoch-Schönlein syndrome underwent a careful, structured skin examination established in advance with emphasis on the presence of palpable lesions with a linear pattern.

Results  Among the 31 children in the study (12 girls and 19 boys; median age, 6.2 years [range, 3.0-12.0 years]), 8 (26%) had linear lesions on the legs, groin, waistline, wrists, or forearms. Patients with or without linear lesions did not differ significantly with respect to sex, age, and cutaneous, abdominal, articular, or renal involvement.

Conclusions and Relevance  This study illustrates the prevalence and characteristics of linear skin lesions in patients with Henoch-Schönlein syndrome. Patients with symptoms suggestive of this vasculitis should be evaluated for the presence of nonblanching, palpable lesions with a linear pattern.

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