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Observation
December 2017

A Transgender Woman With Anogenital Lichen Sclerosus

Author Affiliations
  • 1Department of Dermatology, University of Tennessee Health Science Center, Memphis
JAMA Dermatol. 2017;153(12):1334-1335. doi:10.1001/jamadermatol.2017.3071

Lichen sclerosus (LS) is a chronic, relapsing, mucocutaneous inflammatory disorder that most commonly presents in anogenital skin. Symptoms include pain, pruritus, dyspareunia, dysuria, and sexual dysfunction; some cases are asymptomatic. Early diagnosis and treatment are critical because the symptoms of vulvar LS can substantially affect quality of life. Early intervention may minimize risk of vulvar atrophy and scarring. There is also a small but well-established risk of malignant transformation to squamous cell carcinoma (SCC) in involved skin, for which long-term monitoring is appropriate.

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