Lichen sclerosus (LS) is a chronic, relapsing, mucocutaneous inflammatory disorder that most commonly presents in anogenital skin. Symptoms include pain, pruritus, dyspareunia, dysuria, and sexual dysfunction; some cases are asymptomatic. Early diagnosis and treatment are critical because the symptoms of vulvar LS can substantially affect quality of life. Early intervention may minimize risk of vulvar atrophy and scarring. There is also a small but well-established risk of malignant transformation to squamous cell carcinoma (SCC) in involved skin, for which long-term monitoring is appropriate.
McMurray SL, Overholser E, Patel T. A Transgender Woman With Anogenital Lichen Sclerosus. JAMA Dermatol. 2017;153(12):1334–1335. doi:10.1001/jamadermatol.2017.3071
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