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Observation
December 2017

Human Papillomavirus–Induced Atypical Pigmented High-grade Dysplasia of the Scrotum

Author Affiliations
  • 1Department of Dermatology, Venerology, and Allergology, HELIOS St Elisabeth Hospital Oberhausen, University Witten/Herdecke, Germany
  • 2Institute of Virology, National Reference Center for Papilloma- and Polyomaviruses, University of Cologne, Germany
  • 3Institute of Pathology, Mülheim an der Ruhr, Germany
JAMA Dermatol. 2017;153(12):1332-1334. doi:10.1001/jamadermatol.2017.3712

Human papillomaviruses (HPVs) of the alpha genus induce a wide spectrum of epithelial lesions ranging from benign warts to anogenital dysplasia or invasive cancer. Penile intraepithelial neoplasia is a potential penile cancer precursor, and 50% to 90% of cases are induced by high-risk HPV types such as HPV16.1 We herein describe a patient with an unusual HPV-induced pigmented high-grade dysplasia of the scrotum that does not fit into the established clinical classification of anogenital HPV-associated lesions.

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