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Physicians and insurance companies use clinical practice guidelines (CPGs) to make decisions about patient care. These guidelines include recommendations derived from a systematic review of research evidence and careful consideration of benefits and harms associated with medical interventions. In this cross-sectional study of 49 CPG authors, Checketts et al reveal that 40 had received industry payments, and 22 did not accurately disclose their industry relationships. Changes are recommended for panel composition, disclosure policies, and development practices to promote transparency and minimize bias.
Chronic urticaria (CU) affects 0.1% to 0.3% of children and is defined by the occurrence of wheals or angioedema lasting more than 6 weeks. It is often considered a self-limited disease in adults, but data on the natural history of CU in children are scarce. In this cohort study, Netchiporouk et al demonstrate that the yearly resolution rate of CU in children was only 10%. Basopenia and positive results from a basophil activation test (CD63 <1.8%) were associated with higher resolution rates. Clarifying the mechanisms accounting for these associations may allow development of appropriate management strategies.
Highlights. JAMA Dermatol. 2017;153(12):1207. doi:https://doi.org/10.1001/jamadermatol.2016.1728
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