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JAMA Dermatology Clinical Evidence Synopsis
February 2018

Interventions for Nongenital Molluscum Contagiosum in Persons Without Immune Deficiency

Author Affiliations
  • 1Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, VU University Medical Center Amsterdam, Netherlands
  • 2Department of General Practice, Erasmus MC University Medical Center, Rotterdam, Netherlands
  • 3Department of Dermatology, Kaiser Permanente, San Francisco, California
JAMA Dermatol. 2018;154(2):203-204. doi:10.1001/jamadermatol.2017.5118

Clinical Question  How effective and safe are treatments for nongenital molluscum contagiosum in persons without immune deficiency?

Bottom Line  Compared with placebo, imiquimod, 5%, cream was not more effective in clearing molluscum contagiosum and caused more local adverse effects, including application site reactions, in children aged 2 to 12 years; because high-quality evidence for other interventions is lacking, allowing for natural resolution of the infection remains a reasonable approach.

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