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Research Letter
February 2018

Association of Uterine Leiomyomas With Central Centrifugal Cicatricial Alopecia

Author Affiliations
  • 1Meharry Medical College, Nashville, Tennessee
  • 2Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland
JAMA Dermatol. 2018;154(2):213-214. doi:10.1001/jamadermatol.2017.5163

Central centrifugal cicatricial alopecia (CCCA) is a primary cicatricial alopecia that predominantly affects black women.1 Although the exact prevalence is unclear, CCCA is the most common form of permanent alopecia in this population.2 For most patients with CCCA, the effect of hair loss can be psychologically devastating, affecting social functioning and personal relationships.3 Past studies have attempted to implicate hairstyling habits in the pathogenesis of CCCA, but no clear associations have been established.4 Histologically, CCCA can display a lymphocytic perifollicular infiltrate that progresses to end-stage fibrosis out of proportion to the degree of clinical signs of inflammation.1

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