Vitiligo is an autoimmune disease that results in disfiguring white patches of skin. Treatment, including topical corticosteroids, topical calcineurin inhibitors, and narrowband UV-B phototherapy, often has limited efficacy.1 Currently, the only vitiligo treatment approved by the US Food and Drug Administration is monobenzyl ether of hydroquinone (MBEH), which is a depigmenting agent. Janus kinase (JAK) inhibitors are a promising class of targeted therapy,1-4 though concomitant low-dose light treatment may be necessary to stimulate melanocytes to achieve repigmentation.5,6 Herein, we describe 2 patients with vitiligo with significant facial involvement treated successfully with tofacitinib, a JAK 1/3 inhibitor, plus low-dose, narrowband UV-B.