Erythema multiforme (EM) is a hypersensitivity skin condition involving T-cell and B-cell responses for which the main causes are infectious factors (eg, herpes simplex virus, Mycoplasma pneumoniae). Antiplakin autoantibodies are found in some patients. EM has a chronic course (ie, recurrent or subintrant) in 40% of cases. Mucous membrane involvement causes relevant morbidity and impairs quality of life.1
Drahy F, Ingen-Housz-Oro S, Grootenboer-Mignot S, Wolkenstein P, Chosidow O. Lenalidomide as an Alternative to Thalidomide for Treatment of Recurrent Erythema Multiforme. JAMA Dermatol. 2018;154(4):487–489. doi:10.1001/jamadermatol.2017.5889
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