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February 21, 2018

Mepolizumab Treatment of Pediatric Eosinophilic Granulomatosis With Polyangiitis

Author Affiliations
  • 1Division of Dermatology, Augusta University, Augusta, Georgia
JAMA Dermatol. Published online February 21, 2018. doi:10.1001/jamadermatol.2017.5888

Eosinophilic granulomatosis with polyangiitis (EGPA or Churg-Strauss syndrome) is characterized by asthma, eosinophilia, and systemic vasculitis of multiple organs. We describe a case of rapidly progressive, antineutrophil cytoplasmic antibody (ANCA)-negative EGPA in a teenager that showed improvement after treatment with mepolizumab, an anti–interleukin (IL)-5 monoclonal antibody.

A teenager with asthma reported an eruption on the upper thighs and palms of 1 month’s duration. Additional complaints included right foot numbness and difficulty ambulating. Over the preceding 6 months, the patient had several hospitalizations for an atypical eosinophilic pneumonia, pleural effusion, and pericarditis requiring management with continuous positive airway pressure.

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