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April 2018

Immunophenotypic CD56 Variation Within a Single Patient With Blastic Plasmacytoid Dendritic Cell Neoplasm

Author Affiliations
  • 1Columbia University College of Physicians and Surgeons, New York, New York
  • 2Department of Dermatology, Columbia University Medical Center, New York, New York
JAMA Dermatol. 2018;154(4):492-494. doi:10.1001/jamadermatol.2017.6061

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic cancer with strong skin tropism. It is classically defined by the coexpression of CD4 and CD56 antigens; however, phenotypic variations have been reported. Herein, we describe a case of BPDCN in which the skin biopsy specimen was CD56, but bone-marrow biopsy and peripheral flow cytometry findings were CD56+, demonstrating that phenotypic variability can be observed within a single patient.