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JAMA Dermatology Clinicopathological Challenge
March 14, 2018

Disseminated Asymptomatic Papules Over the Body

Author Affiliations
  • 1Department of Dermatology, Peking University First Hospital, Beijing, China
  • 2Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China
JAMA Dermatol. Published online March 14, 2018. doi:10.1001/jamadermatol.2017.6054

A woman in her 30s presented with a 15-year history of generalized asymptomatic papules on her body. The lesions had initially started from her left arm and gradually progressed to her trunk, legs, neck, and face in a symmetrical pattern within 1 year. She was otherwise healthy and had no family history of similar symptoms. Physical examination revealed widespread, monomorphic, skin-colored to red-brown papules 2 to 4 mm in diameter, and symmetrically distributed over her trunk, extremities, neck, forehead, and periocular regions (Figure, A and B). Punch biopsy specimens were obtained from the abdomen (Figure, C).

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