[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 35.175.212.130. Please contact the publisher to request reinstatement.
Observation
July 2018

Osteopenia and Multiple Fractures in an Infant With Harlequin Ichthyosis

Author Affiliations
  • 1Department of Dermatology, Oslo University Hospital, Oslo, Norway
  • 2Center for Rare Disorders, Oslo University Hospital, Oslo, Norway
  • 3Department of Radiology, Oslo University Hospital, Oslo, Norway
  • 4Department of Pediatrics, Oslo University Hospital, Oslo, Norway
JAMA Dermatol. 2018;154(7):847-849. doi:10.1001/jamadermatol.2018.0308

Harlequin ichthyosis (HI) is a rare form of autosomal-recessive congenital ichthyosis associated with significant perinatal morbidity and mortality. At birth, platelike scales separated by rhagades create the characteristic diamond-shaped skin manifestations. Advances in neonatal intensive care and, presumably, early administration of oral retinoid therapy has markedly improved survival.1

×