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May 2, 2018

Intralesional Deoxycholic Acid Treatment for Fibrofatty Residua of Involuted Infantile HemangiomasA Novel Therapeutic Approach

Author Affiliations
  • 1MedStar Washington Hospital Center, MedStar Georgetown University Hospital, Washington, DC
JAMA Dermatol. Published online May 2, 2018. doi:10.1001/jamadermatol.2018.0617

Infantile hemangiomas (IHs) are the most common soft-tissue tumor of infancy, with a prevalence of 4.5%.1 They appear shortly after birth, grow to peak size by about 9 months of age, and then involute over months to years. Up to 70% of the time when left untreated, the process of vascular degeneration results in permanent sequelae such as telangiectasia, anetoderma, and/or excess fibrofatty tissue, all of which can cause significant cosmetic or functional concerns.1 Treatment of fibrofatty residua (FFR) is primarily surgical, with laser, liposuction, and nonablative fractional photothermolysis representing other options.2-4 We report the first case to our knowledge of FFR successfully treated with intralesional deoxycholic acid (DCA).

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