To the Editor Treatment with topical fluorouracil, 5%, compared with placebo reduced risk of surgically treated squamous cell carcinoma (SCC) and Mohs surgery for keratinocyte carcinoma (KC) for 1 year, according to a randomized clinical trial (RCT) report.1 However, because neither of these outcomes was prespecified, these findings should be interpreted very cautiously and should not sway clinical practice.
Katz KA. Problematic End Points in a Trial of Topical Fluorouracil, 5%, for Chemoprevention of Keratinocyte Carcinoma. JAMA Dermatol. 2018;154(7):850–851. doi:10.1001/jamadermatol.2018.1229
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