Lichen myxedematosus (LM) encompasses a spectrum of diseases associated with dermal mucin deposition and varying systemic involvement. Herein we report a case of atypical LM (ALM) associated with hepatitis C virus (HCV) that entirely resolved following curative treatment of HCV.
A man in his 60s with chronic, treatment-naive HCV presented with an 18-month history of progressive waxy pink papules and plaques overlying bony prominences of the face, leading to leonine facies (Figure 1A). Additionally, similar papules on the neck (Figure 1B), scalp, and distal upper extremities as well as paresthesias, arthralgias, and reduced articular mobility of the bilateral hands were present.
Jones KM, Shelton ME, Soldano AC, Campbell J. Resolution of Atypical Lichen Myxedematosus Following Successful Treatment of Chronic Hepatitis C Virus Infection With Sofosbuvir-Velpatasvir Combination Therapy. JAMA Dermatol. 2018;154(9):1094–1096. doi:10.1001/jamadermatol.2018.2379
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