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September 2018

Resolution of Atypical Lichen Myxedematosus Following Successful Treatment of Chronic Hepatitis C Virus Infection With Sofosbuvir-Velpatasvir Combination Therapy

Author Affiliations
  • 1Division of Dermatology, Dell Medical School at the University of Texas at Austin
  • 2Division of Dermatopathology, Clinical Pathology Associates, Austin, Texas
  • 3Division of Dermatology, Department of Veterans Affairs, Central Texas Veterans Health Care System, Austin Outpatient Clinic, Austin
JAMA Dermatol. 2018;154(9):1094-1096. doi:10.1001/jamadermatol.2018.2379

Lichen myxedematosus (LM) encompasses a spectrum of diseases associated with dermal mucin deposition and varying systemic involvement. Herein we report a case of atypical LM (ALM) associated with hepatitis C virus (HCV) that entirely resolved following curative treatment of HCV.

A man in his 60s with chronic, treatment-naive HCV presented with an 18-month history of progressive waxy pink papules and plaques overlying bony prominences of the face, leading to leonine facies (Figure 1A). Additionally, similar papules on the neck (Figure 1B), scalp, and distal upper extremities as well as paresthesias, arthralgias, and reduced articular mobility of the bilateral hands were present.

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