Severe aplastic anemia (SAA) is a rare disease in which the bone marrow cannot produce adequate supplies of cells. A more recent and curative approach to SAA includes allogenic hematopoietic stem-cell transplantation (allo-HCT). Graft-vs-host disease (GVHD) is one of the most frequent complications of allo-HCT and is associated with high morbidity and mortality.1 In both its acute and chronic subtypes, GVHD manifests in multiple organs. Chronic GVHD affects 30% to 70% of patients, with an onset of 4 to 6 months after transplant.2
Borg MA, Shalabi RA, Childs R, Wells BC. Alopecia Universalis and Chronic Graft-vs-Host Disease Treated With Ruxolitinib. JAMA Dermatol. 2018;154(11):1357–1358. doi:10.1001/jamadermatol.2018.2927
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: