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October 24, 2018

Herpetic Whitlow—A Case of Inadvertent Inoculation With Melanoma Viral Therapy

Author Affiliations
  • 1Department of Dermatology, University of Rochester, Rochester, New York
  • 2Department of Surgery, University of Rochester, Rochester, New York
JAMA Dermatol. Published online October 24, 2018. doi:10.1001/jamadermatol.2018.3584

Herpetic whitlow is a manifestation of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) that presents as single or grouped vesicles on the distal extremity after direct contact with an infectious source. Considered an occupational exposure, herpetic whitlow is substantially more common among health care workers and dentists than among the general population owing to frequent and unprotected exposure.1 We present a case of herpetic whitlow arising after self-inoculation of talimogene laherparepvec (T-VEC) by a needlestick injury. T-VEC is an attenuated HSV-1 oncolytic virus used in the treatment of local, recurrent, and unresectable melanoma.

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