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JAMA Dermatology Clinicopathological Challenge
November 28, 2018

Erythematous Papule on the Glans Penis

Author Affiliations
  • 1Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
  • 2Department of Pathology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
JAMA Dermatol. 2019;155(2):247-248. doi:10.1001/jamadermatol.2018.4445

A 60-year-old man with a history of IgA kappa multiple myeloma was referred to our department. He had been diagnosed with multiple myeloma 2 years earlier after discovery of osteolytic bone lesions of the skull and the findings of a bone marrow biopsy. The patient had been treated with bortezomib and dexamethasone followed by autologous blood progenitor cell transplantation, which resulted in complete response. At the time of the consultation, he was free of disease.

The patient was referred for evaluation of an indolent, erythematous papule on his glans penis of 2 weeks’ duration. He denied sexual risk behavior and reported no recent changes in medication. Careful physical examination revealed a shiny, tense, erythematous, hemispherical papule measuring 5 mm in diameter located on the lateral aspect of the glans (Figure 1A). There were no other skin lesions. The lymph nodes were not palpable, and there was no organomegaly. A punch biopsy was performed for histopathological evaluation (Figure 1B and C).

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