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November 28, 2018

Patch Testing and Allergen-Specific Inhibition in a Patient Taking Dupilumab

Author Affiliations
  • 1Department of Dermatology, School of Medicine, University of California, Irvine, Irvine
  • 2Department of Dermatology, University of California, San Francisco, San Francisco
JAMA Dermatol. Published online November 28, 2018. doi:10.1001/jamadermatol.2018.4098

Positive patch test findings after the initiation of dupilumab therapy, an interleukin-4α receptor inhibitor used for moderate-to-severe or recalcitrant atopic dermatitis (AD), have recently been reported,1,2 suggesting that the allergic contact dermatitis (ACD) pathway is not inhibited by dupilumab. We present a case that suggests that the response to dupilumab therapy may be nuanced and that there may be an allergen-specific response.

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