Clinical diagnosis of inherited diseases may be challenging in consanguineous pedigrees, particularly if more than 1 disease is present. However, precision molecular diagnostics via next-generation sequencing technologies has improved the characterization and classification of inherited disorders, including for genodermatoses.1 Herein, we describe a complex phenotype with skin and renal abnormalities that whole-exome sequencing determined to be inheritance of 2 separate autosomal recessive disorders.